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HDAC4(Ser246)/HDAC5(Ser259)/HDAC7(Ser155) Antibody, PE-Cy5 Conjugated

Applications

  • WB

Reactivity

  • Human
  • Mouse

Predicted Reactivity

  • Rat
  • Cow
  • Horse
  • Chicken
  • Rabbit
Overview
Catalog # bs-3073R-PE-Cy5
Product Name HDAC4(Ser246)/HDAC5(Ser259)/HDAC7(Ser155) Antibody, PE-Cy5 Conjugated
Applications WB
Reactivity Human, Mouse
Predicted Reactivity Rat, Cow, Horse, Chicken, Rabbit
Specifications
Conjugation PE-Cy5
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human HDAC4 around the phosphorylation site of Ser246
Modification Site Ser155
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 9759
Subcellular location Nucleus
Synonyms HDAC4Ser246; HDAC5Ser259; HDAC7Ser155; HD 4; HD4; HDAC 4; HDAC A; HDACA; Histone Deacetylase 4; Histone Deacetylase A; KIAA0288; EC 3.5.1.98; HA6116; p-HDAC4Ser246; p-HDAC5Ser259; p-HDAC7Ser155.
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Application Dilution
WB 1:300-5000