Overview |
bs-2992R-PE-Cy5 |
MLK3 Polyclonal Antibody, PE-Cy5 Conjugated |
WB |
Due to the similarity of this protein to MLK1 2 and 4, there is a chance that this antibody will cross-react based on homology. |
Human, Mouse, Rat |
Cow, Horse |
Specifications |
PE-Cy5 |
Rabbit |
KLH conjugated synthetic peptide derived from human MLK3 |
355-460/847 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
4296 |
Q16584 |
Cytoplasm |
MLK3; PTK1; SPRK; MLK-3; MEKK11; Mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase; MAP3K11 |
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. |
Application Dilution |
WB |
1:300-5000 |