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GGT1 Polyclonal Antibody, AbBy Fluor® 647 Conjugated

Applications

  • WB
  • FCM

Reactivity

  • Human

Predicted Reactivity

  • Mouse
  • Rat
Overview
Catalog # bs-2976R-BF647
Product Name GGT1 Polyclonal Antibody, AbBy Fluor® 647 Conjugated
Applications WB, FCM
Reactivity Human
Predicted Reactivity Mouse, Rat
Specifications
Conjugation AbBy Fluor® 647
Host Rabbit
Source KLH conjugated synthetic peptide derived from human GGT1
Immunogen Range 351-460/569
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 2678
Swiss Prot P19440
Subcellular location Cell membrane
Synonyms GGT; GTG; CD224; GGT 1; D22S672; D22S732; Gamma-glutamyltranspeptidase 1; Gamma-glutamyltransferase 1; Glutathione hydrolase 1; Leukotriene-C4 hydrolase; GGT1
Background Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive.
Application Dilution
WB 1:300-5000
FCM 1:20-100