| Overview |
| bs-25044R-Cy7 |
| PAWR Polyclonal Antibody, Cy7 Conjugated |
| WB |
| Human, Mouse, Rat |
| Cow, Rabbit |
| Specifications |
| Cy7 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human PAWR |
| 101-200/340 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| Q96IZ0 |
| 5074 |
| Cytoplasm, Nucleus |
| 2310001G03Rik ; PAR 4 ; PAR-4 ; Pawr ; PAWR_HUMAN ; PRKC Apoptosis WT1 Regulator ; PRKC apoptosis WT1 regulator protein ; Prostate apoptosis response 4 protein ; Prostate apoptosis response protein 4 ; prostate apoptosis response protein PAR-4 ; Transcriptional repressor Par-4-like protein PAWR ; Transcriptional repressor PAR4 ; WT1 Interacting Protein |
| Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. |
| Application Dilution |
| WB |
1:300-5000 |
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