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RAD51D Polyclonal Antibody, Biotin Conjugated

Applications

  • WB
  • ELISA
  • IHC-P

Reactivity

  • Human

Predicted Reactivity

  • Mouse
  • Cow
Overview
Catalog # bs-19726R-Biotin
Product Name RAD51D Polyclonal Antibody, Biotin Conjugated
Applications WB, ELISA, IHC-P
Reactivity Human
Predicted Reactivity Mouse, Cow
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human RAD51D
Immunogen Range 1-100/328
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 5892
Swiss Prot O75771
Subcellular location Nucleus
Synonyms DNA repair protein RAD51 homolog 4; RAD51D; R51H3; RAD51 homolog D RAD51-like protein 3; TRAD; RAD51D; RAD51L3
Background Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
Application Dilution
WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400