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alpha Actinin 4 Polyclonal Antibody

Applications

  • WB
  • FCM
  • IHC-P
  • IF(ICC)

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-1741R
Product Name alpha Actinin 4 Polyclonal Antibody
Applications WB, FCM, IHC-P, IF(ICC)
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source KLH conjugated synthetic peptide derived from human Actinin alpha 4
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 81
Synonyms Actinin alpha 4; alpha-Actinin 4; alpha Actinin-4; actinin 4; actinin4; actinin-4; ACTN 4; ACTN4; DKFZp686K23158; F actin cross linking protein; FSGS 1; FSGS; FSGS1; Non muscle alpha actinin 4.
Background Loading Control Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008].
Application Dilution
WB 1:500-2000
FCM 1:100
IHC-P 1:100-500
IF(ICC) 1:100