Overview |
bs-11842R-BF647 |
Frizzled 9/CD349 Polyclonal Antibody, AbBy Fluor® 647 Conjugated |
WB, IF(ICC) |
This antibody may have slight cross reactivity with Frizzled 10. |
Human |
Mouse, Rat |
Specifications |
AbBy Fluor® 647 |
Rabbit |
KLH conjugated synthetic peptide derived from human Frizzled 9/CD349 |
185-270/591 |
Polyclonal |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target |
8326 |
O00144 |
Cell membrane |
FZD3; CD349; Frizzled-9; Fz-9; hFz9; FzE6; FZD9 |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
Application Dilution |
WB |
1:500-2000 |
IF(ICC) |
1:50-200 |