| Overview |
| bs-11453R |
| CNTN5/Contactin 5 Polyclonal Antibody |
| WB, ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC), ICC |
| Human, Mouse, Rat, Dog, Sheep, Pig, Horse, Rabbit |
| Specifications |
| Unconjugated |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Contactin 5 |
| 801-900/1100 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 53942 |
| Cell membrane |
| Contactin5; Contactin-5; hNB 2; HNB 2s; NB 2; Neural recognition molecule NB 2; CNTN5_HUMAN. |
| Changes in synaptic efficacy can mediate crucial processes during learning and memory formation. Accumulating evidence implicates cell adhesion molecules in activity-dependent synaptic modifications associated with paired-pulse facilitation (PPF), long-term potentiation (LTP) and long-term depression (LTD). Among the cell adhesion molecules involved in these processes are the contactins. Contactins are immunoglobulin superfamily members that play a selective role in synaptic plasticity, PPF and LTD, and may regulate cell-cell interactions contributing to synaptic plasticity in conjunction with other synapse targeting molecules, including paranodin and phosphacan. In addition, contactins are essential components that control expression and distribution of Na+ channels in neurons, junctional attachment at the paranode, and ultimately the physiology of the myelinated nerve. The human Contactin 1 gene encodes a 1,018 amino acid protein. The human Contactin 3 gene encodes a 646 amino acid plasmacytoma-associated neuronal glycoprotein. The human Contactin 5 gene encodes a 1,100 amino acid neural adhesion molecule. The human Contactin 6 gene encodes a 1,028 amino acid neural adhesion molecule. |
| Application Dilution |
| WB |
1:300-5000 |
| ELISA |
1:500-1000 |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
| IF(IHC-P) |
1:50-200 |
| IF(IHC-F) |
1:50-200 |
| IF(ICC) |
1:50-200 |
| ICC |
1:100-500 |
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