AR7

Overview
Catalog #	bs-83130c-5-mg
Product Name	AR7
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Atypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson’s disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
Description	CAS Number: 80306-38-3 Chemical Name: 7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine Molecular weight: 257.72 Formula: C15H12ClNO Solubility: DMSO (30 mg/ml) Physical Properties: Pale pink solid Purity: 98% by TLC NMR (Conforms)