Metolazone

Overview
Catalog #	bs-83120c-50-mg
Product Name	Metolazone
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Activates mitochondrial unfolded protein response (UPRMT) and -increases C. elegans lifespan.4 Clinically useful diuretic that inhibits the thiazide-sensitive Na+-Cl– cotransporter (NCC) (IC50 = 0.3 µM rat), blocking sodium reabsorption.2,3 Metolazone also inhibits human carbonic anhydrase isoforms VII, XII, and XIII with nanomolar potency.4.
Description	CAS Number: 17560-51-9 Chemical Name: 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide Molecular weight: 365.83 Formula: C16H16ClN3O3S Solubility: DMSO (up to 36 mg/ml) Physical Properties: White solid Purity: 98% by HPLC NMR (Conforms)