Locostatin

Overview
Catalog #	bs-83112c-5-mg
Product Name	Locostatin
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Inhibits cell migration by disrupting the interaction between Raf kinase inhibitor protein (RKIP) and Raf-1 kinase.1 Locostatin covalently binds to His86 of RKIP and also disrupts its interaction with G protein-coupled receptor kinase 2.2 Effectively inhibits cytokine release by human lymphocytes.3 Alleviates CCl4-induced liver fibrosis in a mouse model.4 A useful probe to explore the complex functions of RKIP in cell physiology.5
Description	CAS Number: 133812-16-5 Chemical Name: (4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone Molecular weight: 245.28 Formula: C14H15O3 Solubility: DMSO (60 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)