Vacuolin-1

Overview
Catalog #	bs-83098c-5-mg
Product Name	Vacuolin-1
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Vacuolin-1 (351986-85-1) inhibits autophagy via inhibition of Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content and has no effect on other membrane-bound organelles.1 It has been shown to block endosome maturation by activating RAB5 which compromises the biogenesis and function of lysosomes including autophagosomal-lysosomal fusion and endosomal-lysosomal degradation.2 It potently inhibits migration, invasion and colony formation of cancer cells (which is linked to endosomal trafficking) and targets capping protein Zβ (CapZβ) in these processes.3 Inhibition of lysosomal maturation was shown to be due to potent inhibition of PIKfyve.4
Description	CAS Number: 351986-85-1 Chemical Name: 3-Iodobenzaldehyde, 2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone Molecular weight: 577.43 Formula: C26H24IN7O Solubility: DMSO (35 mg/ml) Physical Properties: White solid Purity: >98% by TLC, NMR (Conforms)