PF-543 HCl

Overview
Catalog #	bs-83079c-5-mg
Product Name	PF-543 HCl
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous cell carcinoma cells.2 PF-543 mitigated pulmonary fibrosis via reducing lung epithelial cell mitochondrial DNA damage and monocyte recruitment.3 It also alleviated sepsis-induced lung injury in an acute ethanol intoxication model in mice.4 PF-543 inhibited cell cycle and tumor growth in a xenograft model of non-small cell lung cancer.5
Description	CAS Number: 1706522-79-3 Chemical Name: [(2R)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol hydrochloride Molecular weight: 502.07 Formula: C27H31NO4S·HCl Solubility: DMSO (50 mg/ml); water (5 mg/ml with warming) Physical Properties: White solid Purity: >98% by HPLC NMR (Conforms)