| Overview |
| bsm-10846M-Biotin |
| BCL-2 (1A5) Monoclonal Antibody, Biotin Conjugated |
| WB |
| Human |
| Specifications |
| Biotin |
| Mouse |
| Recombinant protein fragment (1-220 amino acids range) of human Bcl-2. |
| Monoclonal |
| 1A5 |
| IgG |
| 1ug/ul |
| Purified by Protein G. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 596 |
| P10415 |
| Apoptosis regulator Bcl-2; BCL2 |
| Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release |
| Application Dilution |
| WB |
1:300-5000 |
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