SAP49 Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-70253M |
| Product Name | SAP49 Antibody |
| Applications | WB, IHC, ICC |
| Specificity | Specific for endogenous levels of the ~49 kDa SAP49 protein. |
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Mouse |
| Source | Recombinant full length human SAP49 expressed in and purified from E. Coli. |
| Clonality | Monoclonal |
| Clone # | 3A1 |
| Isotype | IgG2b |
| Concentration | Lot Dependent |
| Purification | Purified by Protein G. |
| Storage Buffer | PBS + 50% glycerol and 5 mm NaN3 |
| Storage Condition | Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target | |
| Gene ID | 10262 |
| Swiss Prot | Q15427 |
| Synonyms | AFD1 antibody, Hsh49 antibody, MGC10828 antibody, Pre mRNA splicing factor SF3b 49 kDa subunit antibody, Pre-mRNA-splicing factor SF3b 49 kDa subunit antibody, SAP 49 antibody, SAP49 antibody, Sf3b4 antibody, SF3B4 antibody, SF3B4_HUMAN antibody, SF3b49 antibody, SF3b50 antibody, Spliceosomal protein antibody, Spliceosome associated protein (U2 snRNP) antibody, Spliceosome associated protein 49 antibody, Spliceosome-associated protein 49 antibody, Splicing factor 3b subunit 4 49kDa antibody, Splicing factor 3B subunit 4 antibody |
| Background | The spliceosome associated protein of ~49 kDa (SAP49), also known as SF3B4, is a widely expressed nuclear splicing factor that has been shown to have RNA binding activity as well as direct interaction with SAP145 (Champion-Arnaud and Reed 1994). The SAP145-SAP49 complex has recently been implicated in cell cycle progression as Vpr (viral protein 1 of HIV-1) has been shown to bind SAP145 thus interfering with the proper formation and functioning of the SAP145-SAP49 complex (Terada and Yasuda 2006). |
| Application Dilution | |
| WB | 1:300-5000 |
| IHC | |
| ICC | 1:100-500 |
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