| Overview |
| bsm-70201M |
| Nuclear Pore Complex Antibody |
| ICC |
| Specific for endogenous levels of the nuclear pore complex proteins. |
| Human, Mouse, Rat, Bovine, Chicken, Drosophila |
| Specifications |
| Unconjugated |
| Mouse |
| Yeast nuclear preparations |
| Monoclonal |
| 39C7 |
| IgG1 |
| Lot Dependent |
| Concentrated tissue culture supernatant |
| Concentrated tissue culture supernatent + 10 mM NaN3. |
| Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year. |
| Target |
| 107 kDa nucleoporin antibody, NPC proteins antibody, NU107_HUMAN antibody, Nuclear pore complex protein Nup107 antibody, Nucleoporin 107kDa antibody, Nucleoporin Nup107 antibody, NUP107 antibody, NUP153 antibody, NUP155 antibody, NUP84 antibody, NUP98 antibody |
| The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993; Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001) |
| Application Dilution |
| ICC |
1:100-500 |
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