| Overview |
| bsm-70044M |
| COBRA1 (NELF-B) Antibody |
| WB |
| Specific for endogenous levels of the ~62 kDa COBRA1 protein. |
| Human, Mouse, Rat |
| Specifications |
| Unconjugated |
| Mouse |
| Recombinant full length human COBRA1 purified from E. coli. |
| Monoclonal |
| F7E4 |
| IgG1 |
| Lot Dependent |
| Purified by Protein G. |
| PBS + 0.05% NaN3 |
| Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year. |
| Target |
| 25920 |
| Q8WX92 |
| A730008L03Rik antibody, AB041607 antibody, AI663983 antibody, Cofactor of BRCA1 antibody, DKFZp586B0519 antibody, KIAA1182 antibody, Negative elongation factor B antibody, Negative elongation factor protein B antibody, Nelf b antibody, NELF-B antibody, NELFB antibody, RGD1307832 antibody, RP13-122B23.3 antibody, RP23-132N23.4 antibody |
| COBRA1 (cofactor of BRCA1) also known as NELF-B, is an essential component of the negative elongation factor (NELF) complex. COBRA1 has been shown to directly bind estrogen receptor alpha (ERα) and repress ERα-mediated transcription (Aiyar SE et al., 2004). COBRA1 has also been demonstrated to interact with c-Jun and c-Fos suggesting a role in modulation of the AP-1 pathway and therefore may be important in cell proliferation, differentiation, apoptosis and oncogenesis (Zhong H et al., 2004) |
| Application Dilution |
| WB |
1:300-5000 |
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