Overview |
bsm-62213r-100ul |
MBNL1 Monoclonal Antibody |
WB |
Human, Mouse |
Specifications |
Unconjugated |
Rabbit |
KLH conjugated synthetic peptide derived from human MBNL1 |
Monoclonal |
Recombinant |
IgG |
1ug/ul |
Purified by Protein A. |
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target |
4154 |
Q9NR56 |
Cytoplasm, Nucleus |
EXP; EXP35; EXP40; EXP42; MBNL; MBNL1. |
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. |
Application Dilution |
WB |
:1:1000-1:2000 |