| Overview |
| bsm-61914r-pe-100ul |
| MIB1 Recombinant Monoclonal Antibody, PE Conjugated |
| WB, IF(ICC) |
| Human, Mouse |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human MIB1 |
| Monoclonal |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 57534 |
| Q86YT6 |
| Cytoplasm, Cell membrane |
| Dip1; LVNC7; MIB; mib1; ZZANK2; ZZZ6. |
| E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis. |
| Application Dilution |
| WB |
1:300-5000 |
| IF(ICC) |
1:50-200 |
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