Overview |
bsm-61708r-100ul |
MELK Monoclonal Antibody |
WB |
Human |
Specifications |
Unconjugated |
Rabbit |
KLH conjugated synthetic peptide derived from human MELK |
Monoclonal |
Recombinant |
IgG |
1ug/ul |
Purified by Protein A. |
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target |
9833 |
Q14680 |
Cytoplasm |
hMELK; hPK38; MELK; mKIAA0175; MPK38. |
Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. |
Application Dilution |
WB |
:1:1000-1:2000 |