| Overview |
| bsm-61618r-hrp-100ul |
| ULK3 Recombinant Monoclonal Antibody, HRP Conjugated |
| WB, IHC-P, IHC-F |
| Human, Mouse, Rat |
| Specifications |
| HRP |
| Rabbit |
| KLH conjugated synthetic peptide derived from human ULK3 |
| Monoclonal |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 25989 |
| Q6PHR2 |
| Nucleus |
| Serine/threonine-protein kinase ULK3; Ulk3; unc 51 like kinase 3 (C. elegans); Unc-51-like kinase 3. |
| Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
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