| Overview |
| bsm-61446r-bf680-100ul |
| Cyclin H Recombinant Monoclonal Antibody, AbBy Fluor® 680 Conjugated |
| WB, FCM, IF(ICC) |
| Human, Mouse |
| Specifications |
| AbBy Fluor® 680 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Cyclin H |
| Monoclonal |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 902 |
| P51946 |
| Nucleus |
| CAK; CCNH; CDK-activating kinase; cyclin H; cyclin-dependent kinase-activating kinase; Cyclin-H; MO15-associated protein; p34; p37. |
| Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
| IF(ICC) |
1:50-200 |
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