Overview |
bsm-61196r-100ul |
Phospho-beta Arrestin 1 (Ser412) Monoclonal Antibody |
WB |
Human |
Specifications |
Unconjugated |
Rabbit |
KLH conjugated synthetic peptide derived from human beta Arrestin 1 around the phosphorylation site of S412 |
Ser412 |
Monoclonal |
Recombinant |
IgG |
1ug/ul |
Purified by Protein A. |
10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Target |
408 |
P49407 |
Cytoplasm, Nucleus, Cell membrane |
ARB1; ARR1; ARRB1; Arrestin 2; Arrestin beta 1. |
Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. |
Application Dilution |
WB |
:1:1000-1:2000 |