| Overview |
| bsm-61196r-100ul |
| Phospho-beta Arrestin 1 (Ser412) Recombinant Antibody |
| WB |
| Human |
| Specifications |
| Unconjugated |
| Rabbit |
| KLH conjugated synthetic peptide derived from human beta Arrestin 1 around the phosphorylation site of S412 |
| Ser412 |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 408 |
| P49407 |
| Cytoplasm, Nucleus, Cell membrane |
| ARB1; ARR1; ARRB1; Arrestin 2; Arrestin beta 1. |
| Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. |
| Application Dilution |
| WB |
1:300-5000 |
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