| Overview |
| bsm-61166r-bf488-100ul |
| ASK1 Recombinant Monoclonal Antibody, AbBy Fluor® 488 Conjugated |
| WB, FCM, IF(ICC) |
| Human, Mouse |
| Specifications |
| AbBy Fluor® 488 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human ASK1 |
| Monoclonal |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 4217 |
| Q99683 |
| Cytoplasm |
| Apoptosis signal- regulating kinase 1;ASK-1;MAP3K5;ASK1;MAPKKK5; MEK kinase 5;MEKK5. |
| Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
| IF(ICC) |
1:50-200 |
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