Overview |
bsm-54759R |
CD35 Monoclonal Antibody |
WB, IHC-P |
Human |
Specifications |
Unconjugated |
Rabbit |
Synthetic peptide corresponding to the extracellular domain of human CD35. |
Monoclonal |
3H19 |
IgG |
1ug/ul |
Purified by Protein A. |
Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
Store at -20°C for 12 months. |
Target |
1378 |
P17927 |
Membrane |
C3 binding protein antibody, C3b/C4b receptor antibody, C3BR antibody, C4BR antibody, CD 35 antibody, CD35 antibody, CD35 antigen antibody, complement component (3b/4b) receptor 1 (Knops blood group) antibody, complement component (3b/4b) receptor 1 including Knops blood group system antibody, Complement component receptor 1 antibody, Complement receptor 1 antibody, Complement receptor type 1 antibody, CR 1 antibody, CR1 antibody, CR1_HUMAN antibody, KN antibody, Knops blood group antigen antibody |
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. |
Application Dilution |
WB |
1:300-5000 |
IHC-P |
1:200-400 |