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GOT2 Monoclonal Antibody

Applications

  • WB
  • FCM
  • IHC-P

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bsm-54731R
Product Name GOT2 Monoclonal Antibody
Applications WB, FCM, IHC-P
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source Synthetic Peptide within Human GOT2.
Clonality Monoclonal
Clone # 4H6
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 2806
Swiss Prot P00505
Subcellular location Cell membrane, Mitochondrion matrix
Synonyms AATM_HUMAN antibody, AL022787 antibody, Aspartate aminotransferase 2 antibody, Aspartate aminotransferase antibody, Aspartate aminotransferase, mitochondrial antibody, Aspartate transaminase 2 antibody, ASPATA antibody, EC 2.6.1.1 antibody, FABP 1 antibody,
Background GOT2 [Glutamate oxaloacetate transaminase] is a ubiquitous pyridoxal phosphate dependent enzyme which exists in both mitochondrial and cytosolic forms. The enzyme plays an important role in amino acid metabolism and in the urea and tricarboxylic acid cycles. The 2 isoenzymes are homodimeric. In liver about 80% of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic. Although the mitochondrial and soluble forms of GOT are coded by different chromosomes, the 2 show close homology in amino acid sequence and were presumably derived from a common ancestral gene. Serum GOT [with SGPT] levels are usually elevated in states of hepatocellular injury (injury to the liver cells), the highest levels are associated with hepatitis of a viral origin. High levels are also found after myocardial infarction, when SGPT levels are lower.
Application Dilution
WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400