DOK1 Monoclonal Antibody

Overview
Catalog #	bsm-54734R
Product Name	DOK1 Monoclonal Antibody
Applications	WB
Reactivity	Human, Rat
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	Synthetic Peptide corresponding to Human DOK1.
Clonality	Monoclonal
Clone #	5H2
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition	Store at -20°C for 12 months.
Target
Gene ID	1796
Swiss Prot	Q99704
Subcellular location	Cytoplasm, Nucleus, Perinuclear region
Synonyms	Docking protein 1 62kD antibody, Docking protein 1 antibody, DOK 1 antibody, DOK1 antibody, DOK1_HUMAN antibody, Downstream of tyrosine kinase 1 antibody, p62(dok) antibody, P62DOK antibody, pp62 antibody
Background	Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Application Dilution
WB	1:300-5000