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PPP1CB (6G6) Monoclonal Antibody

Applications

  • WB
  • IHC-P
  • IP

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bsm-54463R
Product Name PPP1CB (6G6) Monoclonal Antibody
Applications WB, IHC-P, IP
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant protein corresponding to human PPP1CB aa 100-327.
Clonality Monoclonal
Clone # 6G6
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 5500
Swiss Prot P62140
Subcellular location Cytoplasm, Nucleus
Synonyms Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase 1 catalytic subunit beta; PP-1B; PPP1CD; PP1beta
Background Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective.
Application Dilution
WB 1:300-5000
IHC-P 1:200-400
IP 1-2ug