New to Bioss? Enjoy 35% of your first order. Use code "FirstOrder35" - Offer valid for new U.S. Customers on direct orders only

PICK1 (4G1) Monoclonal Antibody

Applications

  • WB
  • FCM
  • IP

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bsm-54393R
Product Name PICK1 (4G1) Monoclonal Antibody
Applications WB, FCM, IP
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant protein within N-terminal human PICK1.
Clonality Monoclonal
Clone # 4G1
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID 9463
Swiss Prot Q9NRD5
Subcellular location Cell membrane, Cytoskeleton
Synonyms PRKCA-binding protein; Protein interacting with C kinase 1; protein interacting with PRKCA 1; Protein kinase C-alpha-binding protein; PICK1; PRKCABP
Background Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
Application Dilution
WB 1:300-5000
FCM 1:20-100
IP 1-2ug