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EGR2 (5C5) Monoclonal Antibody

Applications

  • WB
  • FCM

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bsm-54391R
Product Name EGR2 (5C5) Monoclonal Antibody
Applications WB, FCM
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant protein within human EGR2 aa 1-200.
Clonality Monoclonal
Clone # 5C5
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Target
Swiss Prot P11161
Subcellular location Nucleus
Synonyms E3 SUMO-protein ligase EGR2; AT591; E3 SUMO-protein transferase ERG2; Early growth response protein 2; Zinc finger protein Krox-20; EGR-2; EGR2; KROX20
Background The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene.
Application Dilution
WB 1:300-5000
FCM 1:20-100