New to Bioss? Enjoy 35% of your first order. Use code "FirstOrder35" - Offer valid for new U.S. Customers on direct orders only

Fibrinogen gamma chain (10A1) Monoclonal Antibody

Applications

  • WB
  • FCM
  • IHC-P

Reactivity

  • Human
Overview
Catalog # bsm-54380R
Product Name Fibrinogen gamma chain (10A1) Monoclonal Antibody
Applications WB, FCM, IHC-P
Reactivity Human
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant protein corresponding to human Fibrinogen gamma50-250aa.
Clonality Monoclonal
Clone # 10A1
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Target
Gene ID 2266
Swiss Prot P02679
Subcellular location Secreted
Synonyms Fibrinogen gamma chain; FGG
Background Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Application Dilution
WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400