Beclin 1
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bsm-41365r-100ul |
Product Name | Beclin 1 |
Applications | IHC |
Reactivity | Human, Rat |
Predicted Reactivity | Mouse |
Specifications | |
Conjugation | Unconjugated |
Host | Rabbit |
Source | Recombinant human Beclin 1 protein |
Immunogen Range | 141-450/450 |
Clonality | Monoclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Storage Condition | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
Target | |
Gene ID | 8678 |
Swiss Prot | Q14457 |
Subcellular location | Cytoplasm, Cell membrane |
Synonyms | Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN. |
Background | Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. |
Application Dilution | |
IHC | 1:100-500 |