| Overview |
| bsm-33275M-Biotin |
| SGK1 Monoclonal Antibody, Biotin Conjugated |
| IHC-P, IHC-F |
| Human, Mouse, Rat |
| Specifications |
| Biotin |
| Mouse |
| KLH conjugated synthetic peptide derived from human SGK1 |
| Monoclonal |
| 5.00E+11 |
| IgG |
| 1ug/ul |
| Purified by Protein G. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 6446 |
| O00141 |
| Serum/glucocorticoid regulated kinase 1; SGK 1; SGK-1; Serine/threonine protein kinase SGK; Serine/threonine protein kinase Sgk1; Serum and glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase; SGK 1; SGK; SGK1_HUMAN. |
| SGK1 is a protein kinase that plays an important role in cellular stress response. SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels of SGK1 and activity may contribute to conditions such as hypertension and diabetic nephropathy. This protein also mediates cell survival signals, as it has been shown to phosphorylate and negatively regulate the pro apoptotic FOXO3A protein. Ser 422 is a critical site on the protein and may be involved in its activation. |
| Application Dilution |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
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