| Overview |
| bs-7482R-Biotin |
| NOTCH4 Polyclonal Antibody, Biotin Conjugated |
| ELISA, IHC-P, IHC-F |
| Mouse, Rat |
| Human, Dog, Cow, Sheep, Pig, Horse, Rabbit |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human NOTCH4 |
| 1151-1250/2003 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 4855 |
| Q99466 |
| Nucleus, Cell membrane |
| Notch 4; FLJ16302; hNotch 4; hNotch4; INT 3; INT3; MGC74442; Neurogenic locus notch homolog protein 4; NOTC4_HUMAN; NOTCH 3; NOTCH 4; Notch 4 intracellular domain; Notch homolog 4; NOTCH3; Notch4; NOTCH4 protein; OTTHUMP00000062678. |
| Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system. |
| Application Dilution |
| ELISA |
1:500-1000 |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
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