SARM1 Antibody

Applications

Reactivity

Human
Mouse
Rat

Overview
Catalog #	bs-70254R
Product Name	SARM1 Antibody
Applications	WB, ICC
Specificity	Specific for endogenous levels of the ~79 kDa SARM1 protein.
Reactivity	Human, Mouse, Rat
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	Full length recombinant human SARM1 protein
Clonality	Polyclonal
Isotype	IgG
Concentration	Lot Dependent
Purification	Antigen Affinity purification from Pooled whole antiserum
Storage Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID	23098
Swiss Prot	Q6SZW1
Synonyms	FLJ36296 antibody, KIAA0524 antibody, MyD88-5 antibody, SAM and ARM-containing protein antibody, SAM domain-containing protein 2 antibody, SAMD2 antibody, SARM 1 antibody, SARM1 antibody, SARM1_HUMAN antibody, Sterile alpha and Armadillo repeat protein antibody, sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila antibody, sterile alpha and HEAT/Armadillo motifs-containing protein antibody, sterile alpha and TIR motif containing 1 antibody, Sterile alpha and TIR motif-containing protein 1 antibody, Sterile alpha and TIR motifs-containing protein 1 antibody, Sterile alpha motif domain-containing protein 2 antibody, Tir-1 homolog antibody
Background	NAD(+) hydrolase sterile alpha and TIR motif-containing protein 1 (SARM1), is the fifth member of the Toll/Il-1 Receptor (TIR) domain protein family. The highly conserved 724 amino acid protein is predominantly expressed in the brain, kidney and liver (Mink, M., et al 2001). Furthermore, SARM1 is enriched in the cytoplasm, mitchondria, and the axons, dendrites, and synapses of neurons (Panneerselvam, P., et al, 2012). SARM1 plays a key role in axonal degeneration by catalyzing the cleavage of NAD+ into ADPR, cADPR, and nicotinamide in response to injury triggering Wallerian degeneration (Gerdts, J. et al 2015). SARM1 has also been shown to activate neuronal cell death in response to stress (Peng, J. et al. 2010).
Application Dilution
WB	1:300-5000
ICC	1:100-500