Phospholipase C β2 (PLC-β2) Antibody

Applications

Reactivity

Human
Non-Human Primate

Overview
Catalog #	bs-70223r-100ul
Product Name	Phospholipase C β2 (PLC-β2) Antibody
Applications	IHC
Specificity	Specific for endogenous levels of PLC β2.
Reactivity	Human, Non-Human Primate
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	Synthetic peptide corresponding to amino acid residues from the C-terminal region of human PLC β2.
Clonality	Polyclonal
Isotype	IgG
Concentration	Lot Dependent
Purification	Antigen Affinity purification from Pooled whole antiserum
Storage Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Target
Gene ID	5330
Swiss Prot	Q00722
Synonyms	1-phosphatidylinositol-4 antibody, 1-phosphatidylinositol-4 5-bisphosphate phosphodiesterase beta-2 antibody, 5-bisphosphate phosphodiesterase beta-2 antibody, FLJ38135 antibody, Phosphoinositide phospholipase C-beta-2 antibody, Phospholipase C-beta-2 antibody, PLC-beta-2 antibody, Plcb2 antibody, PLCB2_HUMAN antibody
Background	Phospholipases are quite common enzymes that are present in a broad range of organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) constitutes a class of enzymes that cleave phospholipids on the diacylglycerol (DAG) side of the phosphodiester bond (Cocco et al., 2015). A growing body of evidence supports the role of phospholipase C (PLC) in the invasion and metastasis of different tumors, including breast cancer (Bertagnolo et al., 2006). PLC-β2 has been shown to be required for sweet, umami and bitter taste perception in mammals (Zhang et al., 2003). Data also suggests that PLC-β2 serves an unappreciated role assembling components of the p38MAPK signaling module (Barr et al., 2002).
Application Dilution
IHC