| Overview |
| bs-70073r-100ul |
| DsbA-L (Disulfide-bond-A oxidoreductase-like protein) Antibody |
| WB, IHC |
| Specific for endogenous levels of the ~25 kDa DsbA-L protein. It is suggested that you add 1% BSA to the antibody dilution buffer. |
| Human, Mouse |
| Specifications |
| Unconjugated |
| Rabbit |
| Full length recombinant mouse DsbA-L protein. |
| Polyclonal |
| IgG |
| Lot Dependent |
| whole antiserum |
| whole antiserum in 40% glycerol |
| Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year. |
| Target |
| Q9DCM2 |
| DSBA like thioredoxin domain containing protein antibody, Glutathione S-transferase kappa 1, EC:2.5.1.18, GST 13-13, GST class-kappa, GST kappa, GSTK1-1, mGSTK1, Glutathione S-transferase subunit 13 |
| Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Polymorphism of DsbA-L gene has recently been implicated in insulin secretion and body fat distribution (Gao F et al., 2009). Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes. Recent studies identify DsbA-L as a key regulator for adiponectin biosynthesis (Liu et al., 2008). |
| Application Dilution |
| WB |
1:300-5000 |
| IHC |
|
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