| Overview |
| bs-70032r-100ul |
| CaSR Antibody |
| WB |
| Specific for endogenous levels of the ~130-260 kDa CaSR protein. |
| Human, Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| Synthetic peptide from the N-terminus region of rat calcium sensing receptor, conjugated to keyhole limpet hemocyanin (KLH). |
| Polyclonal |
| IgG |
| Lot Dependent |
| Antigen Affinity purification from Pooled whole antiserum |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 24247 |
| P48442 |
| Ca sensing receptor antibody, Ca2+ sensing receptor 1 antibody, Ca2+ sensing receptor antibody, Calcium sensing receptor antibody, CAR antibody, CaSR antibody, CASR_HUMAN antibody, Extracellular calcium sensing receptor antibody, Extracellular calcium sensing receptor [Precursor] antibody, Extracellular calcium-sensing receptor antibody, FHH antibody, FIH antibody, GPRC2A antibody, HHC antibody, HHC1 antibody, Hypocalciuric hypercalcemia 1 antibody, Hypocalciuric hypercalcemia 1 severe neonatal hyperparathyroidism antibody, MGC138441 antibody, NSHPT antibody, Parathyroid Ca(2+) sensing receptor 1 antibody, Parathyroid Cell calcium sensing receptor antibody, Parathyroid Cell calcium-sensing receptor antibody, PCAR 1 antibody, PCaR1 antibody |
| Calcium sensing receptor, CaSR, is a unique G protein-coupled receptor activated by extracellular Ca2+, Mg2+, Sr2+, Mn2+, Ba2+, Ni2+, Al2+, Gd3+, amino acids, polyamines, pH and ionic strength (Quinn, S.J. et al., 1998). CaSR is a cell surface dimer located in the caveolin-rich plasma membrane domains (Kifor, O., et al., 1998). CaSR tightly regulates extracellular calcium levels to avoid hyper/hypo-calcemia through complex interactions with PTH, calcitonin, and vitamin D by balancing their effects on the parathyroid glands, bone, kidney, and intestine (Díaz-Soto, G. et al., 2016). Additionally, CaSR has been identified in the nervous system and recent studies suggest CaSR as a direct target of reducing Aβ42 secretion that may contribute to Alzheimer’s Disease (Armato, U., et al., 2013). Recent studies have shown CaSR negatively impacts the formation and progression of neuroblastomas by calcium exposure leading NB cells overexpressing CaSR to undergo apoptosis by means of activating ERK1/2 (Casalà, C., et al., 2013). |
| Application Dilution |
| WB |
1:300-5000 |
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