| Overview |
| bs-6380R-HRP |
| ERCC6L Polyclonal Antibody, HRP Conjugated |
| IHC-P, IHC-F |
| Human, Mouse, Rat, Cow, Sheep, Pig, Horse |
| Specifications |
| HRP |
| Rabbit |
| KLH conjugated synthetic peptide derived from human ERCC6L |
| 301-400/1250 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C; for long storage, store at -80°C. Avoid multiple freeze-thaw cycles |
| Target |
| 54821 |
| Nucleus |
| ATP dependent helicase ERCC6 like; DNA excision repair protein ERCC 6 like; ERCC 6L; ERCC6L; Excision repair cross complementing rodent repair deficiency complementation group 6 like; Excision repair protein ERCC6 like; FLJ20105; MGC131695; PICH; Plk1 interacting checkpoint helicase; SNF2/RAD54 family protein; Tumor antigen BJ HCC 15; ERC6L_HUMAN. |
| ERCC6L belongs to the SNF2 ATPase family and acts as an essential component of the spindle assembly checkpoint. It contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. It acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L may also play a role in the teratogenic action of alcohol. |
| Application Dilution |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
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