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Beta-catenin Polyclonal Antibody

Applications

  • WB
  • FCM
  • IHC-P
  • IP
  • IHC

Reactivity

  • Human
  • Mouse
  • Rat
Overview
Catalog # bs-55228R
Product Name Beta-catenin Polyclonal Antibody
Applications WB, FCM, IHC-P, IP, IHC
Reactivity Human, Mouse, Rat
Specifications
Conjugation Unconjugated
Host Rabbit
Source A synthetic peptide corresponding to a sequence within amino acids 650-750 of human beta-catenin (NP_001895.1).
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 1499
Swiss Prot P35222
Subcellular location Nucleus, Cell membrane, Intracellular
Synonyms CTNNB;MRD19;armadillo;beta Catenin;CTNNB1
Background The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Application Dilution
WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IP 1-2ug
IHC