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MSH6 Polyclonal Antibody

Applications

  • WB
  • IHC
  • IF

Reactivity

  • Human
  • Mouse
  • Monkey
Overview
Catalog # bs-55135R
Product Name MSH6 Polyclonal Antibody
Applications WB, IHC, IF
Reactivity Human, Mouse, Monkey
Specifications
Conjugation Unconjugated
Host Rabbit
Source Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1).
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 2956
Swiss Prot P52701
Subcellular location Nucleus
Synonyms MSH6;GTBP;GTMBP;HNPCC5;HSAP;p160
Background This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
Application Dilution
WB 1:300-5000
IHC
IF