| Overview |
| bs-51068R |
| EHMT1 Polyclonal Antibody |
| WB, ELISA |
| Human, Mouse |
| Specifications |
| Unconjugated |
| Rabbit |
| Polyclonal antibody raised in rabbit against mouse Ehmt1, using three KLH-conjugated synthetic peptides containing a sequence from the central part of the protein |
| Polyclonal |
| Not determined |
| Not Determined |
| Whole antiserum from rabbit containing 0.05% azide |
| Serum with 0.05% sodium azide. |
| Store at -20°C for 12 months. |
| Target |
| 79813 |
| Q9H9B1 |
| Histone-lysine N-methyltransferase EHMT1, EHMT1, GLP1, Lysine N-methyltransferase 1D, H3-K9-HMTase 5, |
| Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. |
| Application Dilution |
| WB |
1:300-5000 |
| ELISA |
1:500-1000 |
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