| Overview |
| bs-4291R-PE |
| BARD1 Polyclonal Antibody, PE Conjugated |
| WB, FCM |
| Human |
| Mouse, Rat, Dog, Cow, Pig, Horse, Chicken |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human BARD1 |
| 101-200/777 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 580 |
| Q99728 |
| Nucleus |
| BRCA1-associated RING domain protein 1; BARD-1; BARD1 |
| Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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