| Overview |
| bs-3415R-FITC |
| TORC2 (Ser171) Polyclonal Antibody, FITC Conjugated |
| WB, FCM |
| Human, Mouse |
| Rat, Dog, Pig |
| Specifications |
| FITC |
| Rabbit |
| KLH conjugated synthetic phosphopeptide derived from human CREB regulated transcription coactivator 2 around the phosphorylation site of Ser171 |
| Ser171 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 200186 |
| Q53ET0 |
| Cytoplasm, Nucleus |
| TORC2; TORC-2; CREB-regulated transcription coactivator 2; Transducer of regulated cAMP response element-binding protein 2; Transducer of CREB protein 2; CRTC2 |
| Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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