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PXR Polyclonal Antibody, Cy3 Conjugated

Applications

  • WB
  • FCM

Reactivity

  • Human
  • Mouse
  • Pig

Predicted Reactivity

  • Rat
  • Cow
  • Horse
Overview
Catalog # bs-2334R-Cy3
Product Name PXR Polyclonal Antibody, Cy3 Conjugated
Applications WB, FCM
Reactivity Human, Mouse, Pig
Predicted Reactivity Rat, Cow, Horse
Specifications
Conjugation Cy3
Host Rabbit
Source KLH conjugated synthetic peptide derived from human PXR
Immunogen Range 51-150/434
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 8856
Swiss Prot O75469
Subcellular location Nucleus
Synonyms BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; NR1I2
Background Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
Application Dilution
WB 1:300-5000
FCM 1:20-100