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PG-C/Pepsinogen 2 Polyclonal Antibody, Biotin Conjugated

Applications

  • ELISA
  • IHC-P
  • IHC-F

Reactivity

  • Human

Predicted Reactivity

  • Mouse
  • Rat
  • Cow
  • Chicken
Overview
Catalog # bs-1551R-Biotin
Product Name PG-C/Pepsinogen 2 Polyclonal Antibody, Biotin Conjugated
Applications ELISA, IHC-P, IHC-F
Reactivity Human
Predicted Reactivity Mouse, Rat, Cow, Chicken
Specifications
Conjugation Biotin
Host Rabbit
Source KLH conjugated synthetic peptide derived from human PG-C
Immunogen Range 21-120/388
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C for 12 months.
Target
Gene ID 5225
Swiss Prot P20142
Subcellular location Secreted
Synonyms PEPC; PGII; Gastricsin; Pepsinogen C; PGC
Background This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq].
Application Dilution
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500