| Overview |
| bs-13903r-100ul |
| Chimaerin 2 Polyclonal Antibody |
| WB |
| Mouse, Rat |
| Human, Cow, Sheep, Pig, Horse, Chicken |
| Specifications |
| Unconjugated |
| Rabbit |
| KLH conjugated synthetic peptide derived from human Chimaerin 2 |
| 251-350/468 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Target |
| 1124 |
| P52757 |
| Cell membrane |
| ARHGAP3;
BCH;
Beta chimerin;
Chimaerin2;
Chimerin (chimaerin) 2;
Chimerin 2;
CHN 2;
CHN2; CHIO_HUMAN;
MGC138360;
Rho GTPase activating protein 3;
RHOGAP3. |
| The Chimaerin gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, an SH2 domain and a Rho-GAP domain. This protein has GTPase-activating protein activity which is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Increased expression of this gene is associated with lymphomas and decreased expression of this gene is associated with high-grade gliomas and breast tumors. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| Application Dilution |
| WB |
=1:500-2000 |
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