| Overview |
| bs-13641R-Biotin |
| GRB 14 Polyclonal Antibody, Biotin Conjugated |
| ELISA, IHC-P, IHC-F |
| This antibody may also detect the similar protein GRB10 due to an 83% sequence similarity in the immunogen sequence. |
| Human |
| Mouse, Rat, Dog, Cow, Sheep, Horse, Chicken, Rabbit |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human GRB 14 |
| 221-320/540 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 2888 |
| Q14449 |
| Cytoplasm, Cell membrane |
| Growth factor receptor-bound protein 14; GRB14 adapter protein; GRB14 |
| Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. |
| Application Dilution |
| ELISA |
1:500-1000 |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
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