| Overview |
| bs-1351R-PE |
| Pan Granzyme Polyclonal Antibody, PE Conjugated |
| WB, FCM |
| Specific towards Granzyme B and Granzyme H |
| Human, Mouse, Others |
| Rat, Cow, Pig |
| Specifications |
| PE |
| Rabbit |
| KLH conjugated synthetic peptide derived from human GZMB |
| 21-130/247 |
| Polyclonal |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 3002 |
| P10144 |
| Cytoplasm |
| HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1; Granzyme B; C11; CTLA-1; Cathepsin G-like 1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; T-cell serine protease 1-3E; GZMB; GRB, Granzyme B, Granzyme H |
| This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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