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HER3 (Tyr1276) Polyclonal Antibody, HRP Conjugated

Applications

  • ELISA
  • IHC-P
  • IHC-F

Reactivity

  • Rat
  • Dog

Predicted Reactivity

  • Human
  • Cow
  • Pig
  • Horse
Overview
Catalog # bs-13092R-HRP
Product Name HER3 (Tyr1276) Polyclonal Antibody, HRP Conjugated
Applications ELISA, IHC-P, IHC-F
Reactivity Rat, Dog
Predicted Reactivity Human, Cow, Pig, Horse
Specifications
Conjugation HRP
Host Rabbit
Source KLH conjugated synthetic phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1276
Modification Site Tyr1276
Clonality Polyclonal
Isotype IgG
Concentration 1ug/ul
Purification Purified by Protein A.
Storage Buffer Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Condition Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Target
Gene ID 2065
Subcellular location Secreted, Cell membrane
Synonyms Her3/ErbB3Tyr1276; p-HRE3 Tyr1276; ErbB 3 phospho Y1276; ERBB3; c erbB 3; c erbB3; ERBB3 protein; erbB3 S; Glial growth factor receptor; HER 3; HER3; LCCS2; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-like protein c ErbB 3; proto-oncogene-like protein c ErbB3; receptor tyrosine protein kinase ERB3; Receptor tyrosine protein kinase erbB 3; Receptor tyrosine protein kinase erbB3; Tyrosine kinase type cell surface receptor HER3; ERBB3_HUMAN.
Background ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. Isoform 2 lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized. Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2); also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord.
Application Dilution
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500